Postdoctoral Fellow Publications

2016

Mandal M, Gardner C, Sun R, Choi H, Lad S, Mishin V, Laskin J, Laskin D (2016) The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury. Toxicol. Appl. Pharmacol. 304:110-120

Eyo U, Murugan M, Wu L (2016) Microglia-neuron communication in epilepsy. Glia. 65(1):5-18 PMCID: PMC5116010

Peng J, Gu N, Zhou L, Eyo U, Murugan, Gan W, Wu L (2016) Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nature Communications. 7:12029. PMCID: PMC4931235

Swiatkowski P, Murugan M, Eyo U, Wang Y, Rangaraju S, Oh S, Wu L (2016) Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience. 318:22-33 PMCID:PMC4753827

2015

Jan Y, Heck D, Casillas R, Laskin D, Laskin J (2015) Thioredoxin cross-linking by nitrogen mustard in lung epithelial cells: formation of multimeric thioredoxin/thioredoxin reductase complexes and inhibition of disulfide reduction. Chem Res Toxicol 28: 2091-103 PMCID:PMC4877171

Yang S, Jan Y, Mishin V, Richardson J, Hossain M, Heindel N, Heck D, Laskin D, Laskin J (2015) Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase. J Pharmacol Exper Ther 352: 529-40 PMCID:PMC4352594

Jan Y, Richardson J, Baker A, Mishin V, Heck D, Laskin D, Laskin J (2015) Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication. Toxicol Appl Pharmacol. 288: 114-20. PMCID: PMC4579064

Beier E, Richardson J (2015) Parkinson’s Disease: animal and in vitro studies on dopaminergic neurotoxicants. In Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders. Elsevier, San Diego. 267-288

Liu J, Tian D, Murugan M, Eyo U, Dreyfus C, Wang W, Wu L (2015) Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage.; J Neurochem. 135: 347-56. PMCID: PMC4721248

Eyo U, Gu N, De S, Dong H, Richardson J, Wu L (2015) Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium. J Neurosci. 35: 2417-22. PMCID: PMC4323526

Gu N, Eyo U, Murugan M, Peng J, Matta S, Dong H, Wu L (2015) Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain Behav Immun. S0889-1591 PMCID:PMC4864135

2014

Wen X, Gibson C, Yang I, Buckley B, Goedken M, Richardson J, Aleksunes L (2014) MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells. Toxicol Sci. 141: 475-83. PMCID:PMC4271045

Bernard J, Lou Y, Peng Q, Li T, Lu Y (2014) PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis. PloS One. 9: e109862. PMCID: PMC4199678

Bernard J, Lou Y, Peng Q, Li Tao, Vakil P, Ding N, Laskin J, Dong Z, Conney A, Lu Y (2014) Parametrial fat tissue from high fat diet-treated SKH-1 mice stimulates transformation of mouse epidermal JB6 cells. J Carcinog Mutagen. 5: 2157-2518. PMCID: PMC4376014

Bernard J, Lou Y, Peng Q, Li T, Conney A, Lu Y (2014) Inverse relationship between p53 and phospho-Chk1 (Ser317) protein expression in UVB-induced skin tumors in SKH-1 mice. Exp Mol Pathol. 96: 126-31. PMCID: PMC4365929

Jan Y, Heck D, Dragomir A, Gardner C, Laskin D, Laskin J (2014) Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol. 27: 882-94 PMCID: PMC4033643

Jan Y, Heck D, Malaviya R, Casillas R, Laskin D, Laskin J (2014) Cross-linking of thioredoxin reductase by the sulfur mustard analogue mechlorethamine (methylbis(2-chloroethyl)amine) in human lung epithelial cells and rat lung: selective inhibition of disulfide reduction but not redox cycling. Chem Res Toxicol. 27; 61-75 PMCID: PMC4070429

Yochum C, Doherty-Lyon S, Hoffman C, Hossain M, Zelikoff J, Richardson J (2014) Prenatal cigarette smoke exposure causes hyperactivity and aggressive behaviors: role of catecholamines and eeurotrophins. Exp Neurol. 254: 145-152. PMCID: PMC3982151

Richardson J, Roy A, Shalat S, von Stein R, Hossain M, Buckley B, Gearing M, Levey A, German D (2014) Elevated serum pesticide levels and risk for Alzheimer disease. JAMA Neurol. 71:294-90 PMCID: PMC4132934

Eyo U, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu L (2014) Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus. J Neurosci. 34:10528-40. PMCID: PMC4200107

2013

Conney A, Lou Y, Nghiem P, Bernard J, Wagner G, Lu Y (2013) Inhibition of UVB-induced non melanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat. Top Curr Chem. 329: 61-72. PMCID: PMC4049109

Lou Y, Peng Q, Li T, Nolan B, Bernard J, Wagner G, Lin Y, Shih W, Conney A, Lu Y (2013) Oral caffeine during voluntary exercise markedly inhibits skin carcinogenesis and decreases inflammatory cytokines in UVB-treated mice. Nutr Cancer. 65: 1002-13. PMCID: PMC3830615

Yang S, Jan Y, Gray J, Mishin V, Heck D, Laskin D, Laskin J (2013) Sepiapterin reductase mediates chemical redox cycling in lung epithelial cells. J Biol Chem. 288: 19221-37. PMCID:PMC3696693

Sheleg M, Yochum C, Wagner G, Zhou R, Richardson J (2013) Ephrin-A5 deficiency alters sensorimotor and monoaminergic development. Behav Brain Res. 236: 139-47 PMCID: PMC3482281

Rossi-George A, Gow A (2013) Immunofluorescent detection of S-nitrosoproteins in cell culture. Methods. 62: 161-4 PMCID: PMC3766838

Eyo U, Wu L (2013) Bidirectional microglia-neuron communication in the healthy brain. Neural Plast. 2013:456857. PMCID: PMC3775394

2012

Lu Y, Lou Y, Bernard J, Peng Q, Li T, Lin Y, Shih W, Nghiem P, Shapses S, Wagner G, Conney A (2012) Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet. Proc Natl Acad Sci USA. 109: 9065-70. PMCID: PMC3384184

Bernard J, Cowing-Zitron C, Nakatsuji T, Muehleisen B, Muto J, Borkowski A, Martinez L, Greidinger E, Yu Benjamin, Gallo, R (2012) Ultraviolet radiation damages self noncoding RNA and is detected by TLR3. Nat. Med. 18: 1286-90. PMCID: PMC3812946