Researchers are investigating the genetic and environmental contributions to Alzheimer’s and Parkinson’s disease, ADHD, autism, and fetal alcohol syndrome, as well as receptor signaling in the brain. Scientists include Renping Zhou, Joan Bennett, Ken Reuhl, Long-Jon Wu, John McGann, Dipak Sarkar, Ron Hart, Nancy Fielder, Manny DiCicco-Bloom, Troy Roepke, Gary Aston-Jones, Lori White, and Cheryl Dreyfus.
As part of a CounterACT grant, researchers are working to develop new therapies to counter sulfur mustard injury to the lungs, skin, and cornea as well as reduce the toxicity of nerve gases. Scientists include Debra Laskin, Jeff Laskin, Marion Gordon, and Donald Gerecke.
Studies aim to characterize the immune response and molecular mechanisms of drug, diet, and pregnancy-induced liver disease. Scientists include Debra Laskin, Grace Guo, Tracy Anthony, and Lauren Aleksunes.
Metabolism & Transport
Researchers are investigating the metabolism and transport of drugs, environmental chemicals, bile acids, and nutrients. Scientists include Lauren Aleksunes, Grace Guo, Keith Cooper, Brian Buckley, Peter Gilles, and Tony Kong.
Injury to the lung by ozone, particulate matter, and fibrosis is an active area of research. Scientists include Debra Laskin, Andrew Gow, John McGann, Howard Kipen, Rob Laumbach, Reynold Panettieri, and Stephan Schwander.
Inflammation & Tissue Repair
Using multiple models of tissue injury, researchers are identifying the signaling mechanisms underlying inflammation. Scientists include Andrew Gow, Jeff Laskin, Donald Gerecke, Marion Gordon, Chris Molloy, Debra Laskin, and Long-Jon Wu.
Researchers are assessing the ability of environmental chemicals including pesticides, mycotoxins, ethanol, and endocrine-acting chemicals to perturb the neurological, metabolic, and reproductive development of offspring. Scientists include Helmut Zarbl, Lauren Aleksunes, Dipak Sarkar, Lori White, Troy Roepke, Sally Radovick, Phoebe Stapleton, and Mehmet Uzumcu.
Scientists are assessing the effects of environmental chemicals on a variety of species including zebrafish, fruit flies, and other insects and fish and using computational modeling approaches. Scientists include Keith Cooper, Lori White, Joan Bennett, Yana Bromberg, Mark Robson, Joanna Burger, Hao Zhu, and Stephen Burley.
Carcinogenesis & Epigenetics
Active research seeks to identify the influence of epigenetics, circadian rythym on cancer susceptibility, identify novel therapeutic agents, and characterize chemopreventive compounds. Scientists include Suzie Chen, CS Yang, Tony Kong, Bill Belden, Dipak Sarkar, Helmut Zarbl, Nanjoo Suh, and Wei-Xing Zong.
Studies are ongoing to characterize the human exposure to chemicals, risk factors for disease, and potential interventions. Scientists include Howard Kipen, Rob Laumbach, Lauren Aleksunes, Judith Graber, Charles Weschler, Nancy Fiedler, Mark Robson, and Stephan Schwander.