201820172016201520142013

Bircsak KM, Moscovitz JE, Wen X, Archer F, Yuen PYS, Mohammed M, Memon N, Weinberger BI, Saba LM, Vetrano AM, Aleksunes LM. Interindividual regulation of the breast cancer resistance protein/ABCG2 transporter in term human placentas. Drug Metab Dispos. 2018 May;46(5):619-627. PMID: 29386232; PMCID: PMC5896368

Botelho D, Leo BF, Massa C, Sarkar S, Tetley T, Chung KF, Chen S, Ryan MP, Porter A, Atochina-Vasserman EN, Zhang J, Schwander S, Gow AJ. Exposure to silver nanospheres leads to altered respiratory mechanics and delayed immune response in an in vivo murine model. Front Pharmacol. 2018 Mar 26;9:213. PMID: 29632485; PMCID: PMC5879457

Cheng K, Metry M, Felton J, Shang AC, Drachenberg CB, Xu S, Zhan M, Schumacher J, Guo GL, Polli JE, Raufman JP. Diminished gallbladder filling, increased fecal bile acids, and promotion of colon epithelial cell proliferation and neoplasia in fibroblast growth factor 15-deficient mice. Oncotarget. 2018 May 22;9(39):25572-25585. PMID: 29876009; PMCID: PMC5986650

George B, Joy MS, Aleksunes LM. Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy. Exp Biol Med (Maywood). 2018 Feb;243(3):272-282. PMID: 29231123; PMCID: PMC5813872

Hossain MM, Weig B, Reuhl K, Gearing M, Wu LJ, Richardson JR. The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Na(v) 1.6. Exp Neurol. 2018 Oct;308:111-119. PMID: 30017881

Ibrahim ME, Chang C, Hu Y, Hogan SL, Mercke N, Gomez M, O’Bryant CL, Bowles DW, George B, Wen X, Buckley B, Aleksunes L, Joy MS. Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients. Eur J Clin Pharmacol. 2018 Sep 15. Epub ahead of print. PMID: 30220072

Joseph LB, Composto GM, Perez RM, Kim HD, Casillas RP, Heindel ND, Young SC, Lacey CJ, Saxena J, Guillon CD, Croutch CR, Laskin JD, Heck DE. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett. 2018 Sep 1;293:77-81. PMCID: PMC5938161.

Krumm EA, Patel VJ, Tillery TS, Yasrebi A, Shen J, Guo GL, Marco SM, Buckley BT, Roepke TA. Organophosphate flame-retardants alter adult mouse homeostasis and gene expression in a sex-dependent manner potentially through interactions with ERα. Toxicol Sci. 2018 Mar 1;162(1):212-224. PubMed PMID: 29112739.

Pelletier JC, Chen S, Bian H, Shah R, Smith GR, Wrobel JE, Reitz AB. Dipeptide prodrugs of the glutamate modulator riluzole. ACS Med Chem Lett. 2018 Jun 15;9(7):752-756. PMCID: PMC6047042.

Szilagyi JT, Fussell KC, Wang Y, Jan YH, Mishin V, Richardson JR, Heck DE, Yang S, Aleksunes LM, Laskin DL, Laskin JD. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol Appl Pharmacol. 2018 Sep 15;359:102-107. PMID: 30222979

Tiethof AK, Richardson JR, Hart RP. Knockdown of butyrylcholinesterase but not inhibition by chlorpyrifos alters early differentiation mechanisms in human neural stem cells. Toxics. 2018 Sep 1;6(3). pii: E52. PMID: 30200437; PMCID: PMC6160911

Vail G, Roepke TA. Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system. Steroids. 2018 Jan 29. pii: S0039-128X(18)30018-7. PMCID: PMC6064680.

Walley SN, Roepke TA. Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior-An overview. Horm Behav. 2018 May;101:22-28. PMCID: PMC5938167.

Zhang M, Kong B, Huang M, Wan R, Armstrong LE, Schumacher JD, Rizzolo D, Chow MD, Lee YH, Guo GL. FXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice. Dig Liver Dis. 2018 Oct;50(10):1068-1075. PMID: 29730159; PMCID: PMC6168334

Chang C, Hu Y, Hogan SL, Mercke N, Gomez M, O’Bryant C, Bowles DW, George B, Wen X, Aleksunes LM, Joy MS. Pharmacogenomic variants may influence the urinary excretion of novel kidney injury biomarkers in patients receiving cisplatin. Int J Mol Sci. 2017 Jun 22;18(7). pii: E1333. PMID:28640195; PMCID: PMC5535826

Chen HC, Sierra J, Yu LJ, Cerchio R Jr, Wall BA, Goydos J, Chen S. Activation of Grm1 expression by mutated BRaf (V600E) in vitro and in vivo. Oncotarget. 2017;9(5):5861-5875. PMID: 29464040; PMCID: PMC5814180

Chen JX, Liu A, Lee MJ, Wang H, Yu S, Chi E, Reuhl K, Suh N, Yang CS. δ- and γ-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages. Mol Carcinog. 2017 Jan;56(1):172-183. PMID: 27175800; PMCID: PMC5647579

Chen JX, Wang H, Liu A, Zhang L, Reuhl K, Yang CS (2017) From the Cover: PhIP/DSS-Induced Colon Carcinogenesis in CYP1A-Humanized Mice and the Possible Role of Lgr5+ Stem Cells. Toxicol Sci. 155(1):224-233. PMCID: PMC5216652

Cruz K, Guézennec J, Barkay T. Binding of Hg by bacterial extracellular polysaccharide: a possible role in Hg tolerance. Appl Microbiol Biotechnol. 2017 Jul;101(13):5493-5503. PMID: 28396923

Fang M, Kang HG, Park Y, Estrella B, Zarbl H. In vitro bioluminescence assay to characterize circadian rhythm in mammary epithelial cells. J Vis Exp. 2017 Sep 28;(127). PMID: 28994762; PMCID: PMC5752347

Feng S, Dai Z, Liu A, Wang H, Chen J, Luo Z, Yang CS. β-Sitosterol and stigmasterol ameliorate dextran sulfate sodium-induced colitis in mice fed a high fat Western-style diet. Food Funct. 2017 Nov 15;8(11):4179-4186.  PMID: 29034917; PMCID: PMC5875920

Francis M, Groves AM, Sun R, Cervelli JA, Choi H, Laskin JD, Laskin DL (2017) Editor’s Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure. Toxicol Sci. 2017 Feb;155(2):474-484

Francis M, Sun R, Cervelli JA, Choi H, Mandal M, Abramova EV, Gow AJ, Laskin JD, Laskin DL (2017) Editor’s Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury. Toxicol Sci. 155(1):182-195

Francois LN, Gorczyca L, Du J, Bircsak KM, Yen E, Wen X, Tu MJ, Yu AM, Illsley NP, Zamudio S, Aleksunes LM. Down-regulation of the placental BCRP/ABCG2 transporter in response to hypoxia signaling. Placenta. 2017 Mar;51:57-63.  PMID: 28292469; PMCID: PMC5354084

George B, Wen X, Mercke N, Gomez M, O’Bryant C, Bowles DW, Hu Y, Hogan SL, Joy MS, Aleksunes LM. Profiling of kidney injury biomarkers in patients receiving cisplatin: Time-dependent changes in the absence of clinical nephrotoxicity. Clin Pharmacol Ther. 2017 Apr;101(4):510-518. PMID: 28002630; PMCID: PMC5359028

George B, You D, Joy MS, Aleksunes LM. Xenobiotic transporters and kidney injury. Adv Drug Deliv Rev. 2017 Jul 1;116:73-91. PMCID: PMC5519456.

Green AL, Zhan L, Eid A, Zarbl H, Guo GL, Richardson JR. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. 2017 Oct;125:189-196. PMID: 28743636; PMCID: PMC5585058

Isola AL, Chen S. Exosomes: The messengers of health and disease. Curr Neuropharmacol 2017;15(1):157-165. PMID: 27568544; PMCID: PMC5327461

Isola AL, Chen S. Extracellular vesicles: important players in immune homeostasis. Ann Transl Med. 2017 May;5(Suppl 1):S16. PMID: 28567398; PMCID: PMC5440304

Jantzen CE, Toor F, Annunziato KA, Cooper KR. Effects of chronic perfluorooctanoic acid (PFOA) at low concentration on morphometrics, gene expression, and fecundity in zebrafish (Danio rerio). Reprod Toxicol. 2017 Apr;69:34-42. PMID: 28143724; PMCID: PMC5858645

Lin Y, Bircsak KM, Gorczyca L, Wen X, Aleksunes LM. Regulation of the placental BCRP transporter by PPAR gamma. J Biochem Mol Toxicol. 2017 May;31(5). PMID: 27879033; PMCID: PMC5429197

Louis LM, Lerro CC, Friesen MC, Andreotti G, Koutros S, Sandler DP, Blair A, Robson MG, Beane Freeman LE. A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides. Environ Health. 2017 Sep 6;16(1):95.  PMID: 28874165; PMCID: PMC5585902

Magby JP, Richardson JR. Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expression. Neurotoxicology. 2017 May;60:274-279. PMID: 27058123.

Massa CB, Groves AM, Jaggernauth SU, Laskin DL, Gow AJ. Histologic and biochemical alterations predict pulmonary mechanical dysfunction in aging mice with chronic lung inflammation. PLoS Comput Biol. 2017 Aug 24;13(8):e1005570. PMID: 28837561; PMCID: PMC5570219

Moscovitz JE, Yarmush G, Herrera-Garcia G, Guo GL, Aleksunes LM (2017) Differential regulation of intestinal efflux transporters by pregnancy in mice. Xenobiotica. 1-9

Moscovitz JE, Yarmush G, Herrera-Garcia G, Guo GL, Aleksunes LM. Differential regulation of intestinal efflux transporters by pregnancy in mice. Xenobiotica. 2017 Nov;47(11):989-997 PMID: 28043194; PMCID: PMC5495628

Schumacher JD, Kong B, Pan Y, Zhan L, Sun R, Aa J, Rizzolo D, Richardson JR, Chen A, Goedken M, Aleksunes LM, Laskin DL, Guo GL. The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis. Toxicol Appl Pharmacol. 2017 Sep 1;330:1-8. PMID: 28673684; PMCID: PMC5812273

Sheleg M, Yu Q, Go C, Wagner GC, Kusnecov AW, Zhou R. Decreased maternal behavior and anxiety in ephrin-A5(-/-) mice. Genes Brain Behav. 2017 Feb;16(2):271-284. PMID:27535576; PMCID: PMC5812292

Sheleg M, Yu Q, Go C, Wagner GC, Kusnecov AW, Zhou R. Decreased maternal behavior and anxiety in ephrin-A5-/- mice. Genes Brain Behav. 2017 Feb;16(2):271-284. PMCID: PMC5812292.

Sun R, Yang N, Kong B, Cao B, Feng D, Yu X, Ge C, Huang J, Shen J, Wang P, Feng S, Fei F, Guo J, He J, Aa N, Chen Q, Pan Y,Schumacher JD, Yang CS, Guo GL, Aa J, Wang G (2017) Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway. Mol Pharmacol. 91(2):110-122

Sunil VR, Vayas KN, Fang M, Zarbl H, Massa C, Gow AJ, Cervelli JA, Kipen H, Laumbach RJ, Lioy PJ, Laskin JD, Laskin DL (2017) World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp Mol Pathol. 102(1):50-58

Szilagyi JT, Vetrano AM, Laskin JD, Aleksunes LM. Localization of the placental BCRP/ABCG2 transporter to lipid rafts: Role for cholesterol in mediating efflux activity. Placenta. 2017 Jul;55:29-36. PMID: 28623970;  PMCID: PMC5497756

Venosa A, Gow JG, Hall L, Malaviya R, Gow AJ, Laskin JD, Laskin DL. Regulation of nitrogen mustard-induced lung macrophage activation by valproic acid, a histone deacetylase inhibitor. Toxicol Sci. 2017 May 1;157(1):222-234.  PMID: 28184907; PMCID: PMC6075217

Yang W, Zhang Q, Yang Y, Xu J, Fan A, Yang CS, Li N, Lu Y, Chen J, Zhao D, Aa J, Chen X. Epigallocatechin-3-gallate decreases the transport and metabolism of simvastatin in rats. Xenobiotica. 2017 Jan;47(1):86-92. PMID: 27052517

Yu LJ, Wall BA, Wangari-Talbot J, Chen S. Metabotropic glutamate receptors in cancer. Neuropharmacology. 2017 Mar 15;115:193-202. PMCID: PMC4987272.

Bircsak K, Gupta V, Yuen P, Gorczyca L, Weinberger B, Vetrano A, Aleksunes L (2016) Genetic and dietary regulation of glyburide efflux by the human placental breast cancer resistance protein transporter. J Pharmacol Exp Ther. 357:103-113

Botelho DJ, Leo BF, Massa CB, Sarkar S, Tetley TD, Chung KF, Chen S, Ryan MP, Porter AE, Zhang J, Schwander SK, Gow AJ. Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity. Nanotoxicology. 2016;10(1):118-27 PMID: 26152688; PMCID: PMC5033060

Bright AS, Herrera-Garcia G, Moscovitz JE, You D, Guo GL, Aleksunes LM (2016) Regulation of Drug Disposition Gene Expression in Pregnant Mice with Car Receptor Activation. Nucl Receptor Res. 3. PMCID: PMC5090256

Chen J, Li G, Wang H, Liu A, Lee M, Reuhl K, Suh N, Bosland M, Yang C (2016) Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice. Cancer Lett. 371: 71-8. PMCID: PMC4721244

Chen J, Liu A, Lee M, Wang H, Yu S, Chi E, Reuhl K, Suh N, Yang C (2016) ?- and ?-tocopherols Inhibit PhIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages. Mol Carcinogenesis. 56(1):172-183

Composto GM, Laskin JD, Laskin DL, Gerecke DR, Casillas RP, Heindel ND, Joseph LB, Heck DE (2016) Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Exp Mol Pathol. 100:522-531

Cullman SL, Isola AL, Chen S (2016) Exosomes: The messengers of health and disease. Curr Neuropharmacol. 15(1):157-165. 

Dong R, Wang D, Wang X, Zhang K, Chen P, Yang CS, Zhang J (2016) Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice. Redox Biol. 10:221-232. PMCID: PMC5094413.

George B, Wen X, Mercke N, Gomez M, O’Bryant C, Bowles DW, Hu Y, Hogan SL, Joy MS, Aleksunes LM (2016) Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time-Dependent Changes in the Absence of Clinical Nephrotoxicity. Clin Pharmacol Ther. In Press

Isola AL, Chen S (2016) Exosomes: The link between GPCR activation and metastatic potential? Front Genet. 7:56 PMCID: PMC4824768

Isola AL, Eddy K, Chen S. Biology, therapy and implications of tumor exosomes in the progression of melanoma. Cancers (Basel). 2016 Dec 9;8(12).  PMID: 27941674; PMCID: PMC5187508

Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD (2016) Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. Ann N Y Acad Sci. 1378(1):80-86. PMCID: PMC5220671

Jantzen CE, Annunziato KA, Bugel SM, Cooper KR (2016) PFOS, PFNA, and PFOA sub-lethal exposure to embryonic zebrafish have different toxicity profiles in terms of morphometrics, behavior and gene expression. Aquat Toxicol. 175:160-70

Jantzen CE, Annunziato KM, Cooper KR. Behavioral, morphometric, and gene expression effects in adult zebrafish (Danio rerio) embryonically exposed to PFOA, PFOS, and PFNA. Aquat Toxicol. 2016 Nov;180:123-130.  PMID: 27710860; PMCID: PMC5839330

Lacey CJ, Wohlman I, Guillon C, Saxena J, Fianu-Velgus C, Aponte E, Young SC, Heck DE, Joseph LB, Laskin JD, Heindel ND (2016) Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Ann N Y Acad Sci. 1378(1):174-179. PMCID: PMC5063683

Lin Y, Bircsak KM, Gorczyca L, Wen X, Aleksunes LM (2016) Regulation of the placental BCRP transporter by PPAR gamma. J Biochem Mol Toxicol. In Press

Malaviya R, Sunil VR, Venosa A, Vayas KN, Businaro R, Heck DE,Laskin JD, Laskin DL (2016) Macrophages and inflammatory mediators in pulmonary injury induced by mustard vesicants. Ann N Y Acad Sci. 1374(1):168-75. PMCID: PMC5119480

Malaviya R, Sunil VR, Venosa A, Vayas KN, Heck DE, Laskin JD,Laskin DL (2016) Inflammatory mechanisms of pulmonary injury induced by mustards. Toxicol Lett. 244:2-7. PMCID: PMC4753082

Mandal M, Gardner CR, Sun R, Choi H, Lad S, Mishin V, Laskin JD, Laskin DL. The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury. Toxicol Appl Pharmacol. 2016 Aug 1;304:110-20. PMID: 27163765; PMCID: PMC5147741

Moscovitz J, Kong B, Buckley K, Buckley B, Guo G, Aleksunes L (2016) Restoration of enterohepatic bile acid pathways in pregnant mice following activation of the Fxr nuclear receptor. Toxicol Appl Pharmacol. PMCID: PMC5064858

Moscovitz JE, Nahar MS, Shalat SL, Slitt AL, Dolinoy DC, Aleksunes LM. Correlation between conjugated bisphenol A concentrations and efflux transporter expression in human fetal livers. Drug Metab Dispos. 2016 Jul;44(7):1061-5 PMID: 26851240; PMCID: PMC4931889

Schumacher J, Guo G (2016) Regulation of hepatic stellate cells and fibrogenesis by fibroblast growth factors. J Biomed Res Intl. Invited Review. 2016:8323747 PMCID: PMC5028827

Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, Heindel ND, Laskin DL,Laskin JD (2016) Selective targeting of heme protein in cytochrome P450 and nitric oxide synthase by diphenyleneiodonium. Toxicol Sci. 151:150-159 PMCID: PMC4914801

Udasin R, Wen X, Bircsak K, Aleksunes L, Shakarjian M, Kong A, Heck D, Laskin D, Laskin J (2016) Nrf2 regulates the sensitivity of mouse keratinocytes to nitrogen mustard via multidrug resistance-associated protein 1. Toxicol Sci. 149: 202-12. PMCID: PMC4715259

Venosa A, Malaviya R, Choi H, Gow AJ, Laskin JD, Laskin DL (2016) Characterization of distinct macrophage subpopulations during nitrogen mustard-induced lung injury and fibrosis. Am J Respir Cell Mol Biol. 54:436-446

Weig BC, Richardson JR, Lowndes HE, Reuhl KR (2016) Trimethyltin intoxication induces the migration of ventricular/subventricular zone cells to the injured murine hippocampus. Neurotoxicology. 54:72-80

Weinberger B, Malaviya R, Sunil VR, Venosa A, Heck DE, Laskin JD,Laskin DL (2016) Mustard vesicant-induced lung injury: Advances in therapy. Toxicol Appl Pharmacol. 305:1-11. PMCID: PMC5119915

Wohlman IM, Composto GM, Heck DE, Heindel ND, Lacey CJ, Guillon CD, Casillas RP, Croutch CR, Gerecke DR, Laskin DL, Joseph LB, Laskin JD (2016) Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol Appl Pharmacol. 303:30-44

Yang CS, Chen J, Wang H, Lim J (2016) Lessons learned from cancer prevention studies with nutrients and non-nutritive dietary constituents. Mol Nutr Food Res. Epub. 60: 1239-1250

Yu LJ, Wall BA, Chen S (2015) The current management of brain metastasis in melanoma: a focus on riluzole. Expert Rev Neurother. 15(7):779-92

Zhan L, Yang I, Kong B, Shen J, Gorczyca L, Memon N, Buckley B, Guo G (2016) Dysregulation of bile acid homeostasis in parenteral nutrition mouse model. Am J Physiol Gastrointest Liver Physiol. 310(2):G93-G102

Zhan L, Yang I, Kong B, Shen J, Gorczyca L, Memon N, Buckley BT,Guo GL (2016) Dysregulation of bile acid homeostasis in parenteral nutrition mouse model. Am J Physiol Gastrointest Liver Physiol. 310(2):G93-G102.  PMCID: PMC4719060

Atochina-Vasserman E, Guo C, Abramova E, Golden T, Sims M, James M, Beers M, Gow A, Krymskaya V (2015) Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 53: 96-104 PMCID: PMC4566108

Baker A, Guo G, Aleksunes L, Richardson L (2015) Isoform-specific regulation of mouse carboxylesterase expression and activity by prototypical transcriptional activators. J Biochem Mol Toxicol. 29: 545-551 PMCID: PMC4714961

Bircsak K, Aleksunes L (2015) Interaction of isoflavones with the BCRP/ABCG2 drug transporter. Curr Drug Metab. 16: 124-40. PMCID: PMC4713194

Botelho D, Leo B, Massa C, Sarkar S, Tetley T, Chung K, Chen S, Ryan P, Porter A, Zhang J, Schwander S, Gow A (2015) Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity. Nanotoxicology. 10:118-27

Botelho D, Leo B, Massa C, Sarkar S, Tetley T, Chung K, Chen S, Ryan P, Porter A, Zhang J, Schwander S, Gow A (2015) Low-dose AgNPs reduce lung mechanical function and innate immune defense in the absence of cellular toxicity. Nanotoxicology. 10:118-127 PMCID: PMC5033060

Das Gupta S, So JY, Wall B, Wahler J, Smolarek AK, Sae-Tan S, Soewono KY, Yu H, Lee MJ, Thomas PE, Yang CS, Suh N (2015) Tocopherols inhibit oxidative and nitrosative stress in estrogen-induced early mammary hyperplasia in ACI rats. Mol Carcinog. 54:916-925 PMCID: PMC4492905

Green A, Hossain M, Tee S, Zarbl H, Guo G, Richardson J (2015) Epigenetic regulation of dopamine transporter mRNA expression in human neuroblastoma cells. Neurochem Res. 40: 1372-1378 PMCID: PMC4745645

Harvey C, Chen J, Bagnell C, Uzumcu M (2015) Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors alpha and beta in the rat granulosa cell in vitro. Reprod Toxicol. 51: 72-78 PMCID: PMC4465425

Jan Y, Richardson J, Baker A, Mishin V, Heck D, Laskin D, Laskin J (2015) Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication. Toxicol Appl Pharmacol. 288: 114-20. PMCID: PMC4579064

Jin H, Chen J, Wang H, Lu G, Liu A, Li G, Tu S, Lin Y, Yang C (2015) NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate. Nutr Cancer. 67: 167-176. PMCID: PMC4363938

Knudsen L, Atochina-Vasserman EN, Massa C, Birkelbach B, Guo C, Scott P, Haenni B, Beers MF, Ochs M, Gow A (2015) The role of inducible nitric oxide synthase for interstitial remodeling of alveolar septa in surfactant protein D-deficient mice. Am J Physiol Lung Cell Mol Physiol. 309: L959-69 PMCID: PMC4628984

Kung TS, Richardson JR, Cooper KR, White LA (2015) Developmental deltamethrin exposure causes persistent changes in dopaminergic gene expression, neurochemistry, and locomotor activity in zebrafish. Toxicol Sci. 146:235-243. PMCID: PMC4517053

Magby JP, Richardson JR (2015) Role of calcium and calpain in the downregulation of voltage-gated sodium channel expression by the pyrethroid pesticide deltamethrin. J Biochem Mol Toxicol. 29: 129-134 PMCID: PMC4461569

Malaviya R, Gow A, Francis M, Abramova E, Laskin J, Laskin D (2015) Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D. Toxicol Sci. 144: 27-38 PMCID: PMC4349136

Malaviya R, Sunil VR, Venosa A, Verissimo VL, Cervelli JA, Vayas KN, Hall L, Laskin JD, Laskin DL (2015) Attenuation of nitrogen mustard-induced pulmonary injury and fibrosis by anti-tumor necrosis factor-? antibody. Toxicol Sci. 148:71-88PMCID: PMC4659692

Pettit A, Kipen H, Laumbach R, Ohman-Strickland P, Kelly-McNeill K, Cepeda C, Fan Z, Amorosa L, Lubitz S, Schneider S, Gow A (2015) Disrupted nitric oxide metabolism from Type II diabetes and acute exposure to particulate air pollution. PloS One. 10: e0144250 PMCID: PMC4682772

Richardson J, Taylor M, Shalat S, Guillot T, Caudle W, Hossain M, Mathews T, Jones S, Cory-Slechta D, Miller G (2015) Developmental pesticide exposure reproduces features of attention deficit hyperactivity disorder. FASEB J. 29: 1960-1972 PMCID: PMC4415012

Rusu M, Golden T, Wang H, Gow A, Madabhushi A (2015) Framework for 3D histologic reconstruction and fusion with in vivo MRI: Preliminary results of characterizing pulmonary inflammation in a mouse model. Med Phys. 42: 4822-4832 PMCID: PMC4522013

Schumacher J, Guo G (2015) Mechanistic review of drug-induced steatohepatitis. Toxicol Appl Pharmacol. 289:40-47 PMCID: PMC4628855

Sheleg M, Yochum CL, Richardson JR, Wagner GC, Zhou R (2015) Ephrin-A5 regulates inter-male aggression in mice. Behav Brain Res. 286: 300-307. PMCID: PMC4390541

Sunil V, Francis M, Vayas K, Cervelli J, Choi H, Laskin J, Laskin, D (2015) Regulation of ozone-induced lung inflammation and injury by the beta-galactoside-binding lectin galectin-3. Toxicol Appl Pharmacol. 284: 236-245 PMCID: PMC4408237

Teh JL, Shah R, La Cava S, Dolfi SC, Mehta MS, Kongara S, Price S, Ganesan S, Reuhl KR, Hirshfield KM, Karantza V, Chen S. Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells. Breast Cancer Res Treat. 2015 May;151(1):57-73. PMC5193007.

Teh JL, Shah R, Shin SS, Wen Y, Mehnert JM, Goydos J, Chen S. Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor. Pigment Cell Melanoma Res. 2014 Jul;27(4):621-9 PMCID: PMC4061214.

Theodorou I, Botelho D, Schwander S, Zhang J, Chung K, Tetley T, Shaffer M, Gow A, Ryan M, Porter A (2015) Static and dynamic microscopy of the chemical stability and aggregation state of silver nanowires in components of murine pulmonary surfactant. Environ Sci Technol. 49: 8048-56. PMCID: PMC4780758

Venosa A, Malaviya R, Gow AJ, Hall L, Laskin JD, Laskin DL (2015) Protective role of spleen-derived macrophages in lung inflammation, injury, and fibrosis induced by nitrogen mustard. Am J Physiol Lung Cell Mol Physiol. 309:L1487-1498 PMCID: PMC4683320

Venosa A, Malaviya R, Gow AJ, Hall L, Laskin JD, Laskin DL (2015) Protective role of spleen-derived macrophages in lung inflammation, injury, and fibrosis induced by nitrogen mustard. Am J Physiol Lung Cell Mol Physiol. 309(12):L1487-98. PMCID: PMC4683320

Wall BA, Yu LJ, Khan A, Haffty B, Goydos JS, Chen S (2015) Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells. Pigment Cell Melanoma Res. 28:105-109

Xiao J, Wang Q, Bircsak K, Wen X, Aleksunes L (2015) In vitro screening of environmental chemicals identifies zearalenone as a novel substrate of the placental BCRP/ABCG2 transporter. Toxicol Res. 4: 695-706. PMCID: PMC4452124

Bugel S, Bonventre J, White L, Tanguay, R, Cooper, Keith R (2014) Chronic exposure of killifish to a highly polluted environment desensitizes estrogen-responsive reproductive and biomarker genes. Aquat Toxicol. 152: 222-231. PMCID: PMC4084733

Chang YC, Wang JD, Hahn RA, Gordon MK, Joseph LB, Heck DE, Heindel ND, Young SC,Sinko PJ, Casillas RP, Laskin JD, Laskin DL, Gerecke DR (2014) Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol Appl Pharmacol. 280:236-244 PMCID: PMC4254337

Furnari M, Saw C, Kong A, Wagner G (2014) Altered behavioral development in Nrf2 knockout mice following early postnatal exposure to valproic acid. Brain Res Bull. 109: 132-142 PMCID:PMC4367490

Furnari MA, Jobes ML, Nekrasova T, Minden A, Wagner GC. Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Nutr Neurosci. 2014 Apr;17(3):109-15. PMID: 23710594; PMCID: PMC4365912

Jan YH, Heck DE, Dragomir AC, Gardner CR, Laskin DL, Laskin JD (2014) Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol. 27:882-894 PMCID: PMC4033643

Joseph LB, Heck DE, Cervelli JA, Composto GM, Babin MC, Casillas RP, Sinko PJ, Gerecke DR, Laskin DL, Laskin JD. Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard. Exp Mol Pathol. 2014 Jun;96(3):316-27. PMCID: PMC4120277.

Laumbach R, Kipen HM, Ko S, Kelly-McNeil K, Cepeda C, Pettit A, Ohman-Strickland P, Zhang L, Zhang J, Gong J, Veleeparambil M, Gow A (2014) A controlled trial of acute effects of human exposure to traffic particles on pulmonary oxidative stress and heart rate variability. Part Fiber Toxicol. 11: 45 PMCID: PMC4236446

Massa C, Scott P, Abramova E, Gardner C, Laskin D, Gow A (2014) Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol Appl Pharmacol. 278: 53-64 PMCID: PMC4361901

Memon N, Bircsak K, Archer F, Gibson C, Ohman-Strickland P, Weinberger B, Parast M, Vetrano A, Aleksunes L (2014) Regional expression of the BCRP/ABCG2 transporter in term human placentas. Reprod Toxicol. 43: 72-7. PMCID: PMC3946646

Rudraiah S, Moscovitz J, Donepudi A, Campion S, Slitt A, Aleksunes L, Manautou J (2014) Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice. Toxicology. 325: 85-95 PMCID: PMC4428328

Santos-Gandelman JF, Cruz K, Crane S, Muricy G, Giambiagi-deMarval M, Barkay T, Laport MS (2014) Potential application in mercury bioremediation of a marine sponge-isolated Bacillus cereus strain Pj1. Curr Microbiol. 69:374-380

Son Al, Sheleg M, Cooper MA, Sun Y, Kleiman NJ, Zhou R (2014) Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice. Invest Ophthalmol Vis Sci. 55:1594-1606 PMCID: PMC4586972

Sunil V, Vayas K, Cervelli J, Malaviya R, Hall L, Massa C, Gow A, Laskin J, Laskin D (2014) Pentoxifylline attenuates nitrogen mustard-induced acute lung injury, oxidative stress and inflammation. Exp Mol Pathol. 97: 89-98 PMCID: PMC4271840

Wall BA, Wangari-Talbot J, Shin SS, Schiff D, Sierra J, Yu LJ, Khan A, Haffty B, Goydos JS, Chen S (2014) Disruption of GRM1-mediated signaling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res. 27:263-274 PMCID: PMC3947419

Wen X, Gibson CJ, Yang I, Buckley B, Goedken MJ, Richardson JR, Aleksunes LM. MDR1 transporter protects against paraquat-induced toxicity in human and mouse proximal tubule cells. Toxicol Sci. 2014 Oct;141(2):475-83. PMID: 25015657; PMCID: PMC4271045

Yang CS, Wang H, Chen JX, Zhang J. Effects of tea catechins on cancer signaling pathways. Enzymes. 2014;36:195-221. PMID: 27102705; PMCID:PMC5659712

Zheng R, Dragomir AC, Mishin V, Richardson JR, Heck DE, Laskin DL, Laskin JD (2014) Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats. Toxicol Appl Pharmacol. 279:43-52

Zhou H, Chen J, Yang C, Yang MQ, Deng Y, Wang H (2014) Gene regulation mediated by microRNAs in response to green tea polyphenol EGCG in mouse lung cancer. BMC Genomics. 15 Suppl 11: S3. PMCID: PMC4304179

Bircsak K, Gibson C, Robey R, Aleksunes L (2013) Assessment of drug transporter function using fluorescent cell imaging. Curr Protoc Toxicol. 57; Unit 23.6. PMCID: PMC3920305

Bircsak K, Richardson J, Aleksunes L (2013) Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides. J Biochem Mol Toxicol. 27: 157-164. PMCID: PMC4001733

Bonventre J, Kung T, White L, Cooper K (2013) Manipulation of the HIF-Vegf pathway rescues methyl tert-butyl ether (MTBE)-induced vascular lesions. Toxicol Appl Pharmacol. 273: 623-634. PMCID: PMC3898687

Chang YC, Wang JD, Svoboda KK, Casillas RP, Laskin JD, Gordon MK, Gerecke DR (2013) Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model. Toxicol Appl Pharmacol. 268:178-187 PMCID: PMC3768256

Connor A, Chen L, Joseph L, Laskin J, Laskin D (2013) Distinct responses of lung and liver macrophages to acute endotoxemia: role of toll-like receptor 4. Exp Mol Pathol. 94: 216-227 PMCID: PMC3562389

Eldasher L, Wen X Little M, Bircsak K, Yacovino L, Aleksunes L (2013) Hepatic and renal Bcrp transporter expression in mice treated with perfluorooctanoic acid. Toxicology. 306: 108-113. PMCID: PMC3645321

Furnari M, Jobes M, Nekrasova T, Minden A, Wagner G (2013) Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight. Nutr Neurosci. 17:109-115 PMCID: PMC4365912

Furnari M, Jobes M, Nekrasova T, Minden A, Wagner G (2013) Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PloS One. 8: e61321 PMCID: PMC3620390

Groves A, Gow A, Massa C, Hall L, Laskin J, Laskin D (2013) Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation. Am J Physiol Lung Cell Mol Physiol. 305: L555-568 PMCID: PMC3798776

Kozlosky J, Bonventre J, Cooper K (2013) Methyl tert butyl ether is anti-angiogenic in both in vitro and in vivo mammalian model systems. J Appl Toxicol. 33: 820-827. PMCID: PMC4378906

Kutscher H, Gao D, Li S, Massa C, Cervelli J, Deshmukh M, Joseph L, Laskin D, Sinko P (2013) Toxicodynamics of rigid polystyrene microparticles on pulmonary gas exchange in mice: implications for microemboli-based drug delivery systems. Toxicol Appl Pharmacol. 266; 214-223 PMCID: PMC3586786

Moscovitz J, Aleksunes L (2013) Establishment of metabolism and transport pathways in the rodent and human fetal liver. Int J Mol Sci. 14: 23801-23827 PMCID: PMC3876079

Mukherjee D, Botelho D, Gow A, Zhang J, Georgopoulos P (2013) Computational multi scale toxicodynamic modeling of silver and carbon nanoparticle effects on mouse lung function. PloS One. 8: e80917. PMCID: PMC3849047

Ren X, Graham J, Jing L, Mikheev A, Gao Y, Lew J, Xie H, Kim AS, Shang X, Friedman C, Vail G, Fang M, Bromberg Y, Zarbl H (2013) Mapping of Mcs30, a new mammary carcinoma susceptibility quantitative trait locus (QTL30) on rat chromosome 12: identification of fry as a candidate Mcs gene. PloS One. 8:e70930 PMCID: PMC3759375

Sheleg M, Yochum CL, Wagner GC, Zhou R, Richardson JR (2013) Ephrin-A5 deficiency alters sensorimotor and monoaminergic development. Behav Brain Res. 236:139-147. PMCID: PMC3482281

Shi J, Golden T, Guo C, Tu S, Scott P, Lee M, Yang C, Gow A (2013) Tocopherol supplementation reduces NO production and pulmonary inflammatory response to bleomycin. Nitric Oxide. 34: 27-36. PMCID: PMC3769481

Smolarek AK, So JY, Thomas PE, Lee HJ, Paul S, Dombrowski A, Wang CX, Saw CL, Khor TO, Kong AN, Reuhl K, Lee MJ, Yang CS, Suh N (2013) Dietary tocopherols inhibit cell proliferation, regulate expression of ER?, PPAR?, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia. Mol Carcinog. 52:514-525 PMCID: PMC3374909

So JY, Smolarek AK, Salerno DM, Maehr H, Uskokovic M, Liu F, Suh N (2013) Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer. PLoS One. 8:e54020 PMCID: PMC3543376

Sokolowski K, Obiorah M, Robinson K, McCandlish E, Buckley B, DiCicco-Bloom E (2013) Neural stem cell apoptosis after low-methylmercury exposures in postnatal hippocampus produce persistent cell loss and adolescent memory deficits. Dev Neurobiol. 73: 936-949 PMCID: PMC3874131

Son A, Sokolowski K, Zhou R (2013) Cryosectioning. Methods Mol Biol. 1018: 301-311

Son AI, Cooper MA, Sheleg M, Sun Y, Kleiman NJ, Zhou R (2013) Further analysis of the lens of ephrin-A5-/- mice: development of postnatal defects. Mol Vis. 19:254-266 PMCID: PMC3566898

Sunil V, Vayas K, Massa C, Gow A, Laskin J, Laskin D (2013) Ozone-induced injury and oxidative stress in bronchiolar epithelium are associated with altered pulmonary mechanics. Toxicol Sci. 133: 309-319 PMCID: PMC3663562

Yacovino L, Gibson C, Aleksunes L (2013) Down-regulation of brush border efflux transporter expression in the kidneys of pregnant mice. Drug Metab Dispos. 41: 320-325. PMCID: PMC3558863