Research Accomplishments

REGISTER HERE to join Society of Toxicology for a live webinar workshop chaired by Dr. L. Cody Smith – Single Cell Applications in Mechanistic Toxicology – on April 2, 2020 at 12:00 – 1:30 pm EDT.

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Chemical Threats
Presenter Lab Presentation Title
J. Andres D. Laskin The Use of Molecular Imaging Methodology to Develop a Feed-Forward Model to Assess Lung Function in Mustard-Induced Lung Injury
Y. Chang Gerecke Inhibition of Matrix Metalloproteinase 9 (MMP9) Suppresses Inflammation and Enhances Wound Healing in Mouse Skin
M. Gordon Gordon Epithelial Repair in the Rabbit Cornea following Exposure to Sulfur Mustard
Y. Jan J. Laskin Nitrogen Mustard Induces Mitochondria-Mediated Apoptosis Associated with Endoplasmic Reticulum Stress-Regulated MAPK Signaling in Human HaCaT Keratinocytes
L. Joseph J. Laskin Rabbit Conjunctiva as a Target for Ocular Injury Induced by Sulfur Mustard
H. Kim Heck Characterization of Molecular Pattern in Sensory Pain Signaling and Its Neurotransmitters on Mouse Skin following Mustard Exposure
R. Malaviya D. Laskin Pulmonary Effects of Inhaled Sulfur Mustard in Rats
A. Murray D. Laskin Farnesoid X Receptor Regulates Macrophage Activation in Nitrogen Mustard-Induced Lung Injury in a Sex-Dependent Manner
R. Rancourt D. Laskin Microparticle Detection and Phospatidlyserine Exposure in Airway Surface Liquid in Response to Nitrogen Mustard
T. Roldan Sinko Optimizing Nitrogen Mustard Administration to Obtain Reproducible Model Vesicant Skin Burns
V. Sunil D. Laskin Differential Activation of Alveolar Type II Epithelial Cells and Alveolar Macrophages after Nitrogen Mustard Exposure
S. Yang J. Laskin Nitrogen Mustard Targets Pathways for Tetrahydrobiopterin Biosynthesis in Human Keratinocytes
Computational
Presenter Lab Presentation Title
H. Zhu Zhu Nonanimal Models for Animal Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across
K. Zorn Zhu Generation of Machine-Learning Models to Anticipate Endocrine Disruption
Z. Liu Gow INOS-Independent SNO Generation at Low Ph and SNO Prediction Using a Neural Network
Development
Presenter Lab Presentation Title
J. Agudelo Slitt Low-Dose PFOS Exposure Alters the Placental Transcriptome in C57BL/6 Mice
J. D’Errico Stapleton Maternal Health and Placental Outcomes after Pulmonary Nanoplastic Exposure
S. Fournier Stapleton Exposure to Nanomaterials during Gestation Affects Cardiovascular Health for at Least 12 Months
J. Schaefer Babwah Regulation of Mouse Uterine Aquaporin Expression in the Preimplantation Period and the Impact of Ovarian Superovulation
K. Wiersielis Roepke Maternal Exposure to Organophosphate Flame Retardants Alters Locomotor and Anxiety-Like Behavior in Male and Female Adult Offspring
R. Zhang Aleksunes Interaction of the BCRP Transporter with Cadmium in Human Placentas and Cultured Trophoblasts
Education
Presenter Program Presentation Title
J. D’Errico THED Integrating New Technologies into High School Toxicology Education
J. Gray MASOT Expanding the Reach of Undergraduate Education Programs at Regional Meetings: Model Programs at Four Regional SOT Chapters
C. Doherty SURF Team Science in a Summer Undergraduate Fellowship: Field Sampling for Metal Contamination in the Raritan River
Liver and Endocrine
Presenter Lab Presentation Title
F. Alqudrah Yang Can the effects of Green Tea on Gut Microbiota be Sustained?
M. Campbell Guo Fibroblast Growth Factor 15 (FGF15) Suppresses NASH Development in Mice
M. Fang Zarbl Altered SIRT1 Activity and Plasma Cortisol as Biomarkers of Circadian Disruption in Night Shift Workers
K. Frost Goedken Rodent Models for Renal Disposition in Nonalcoholic Steatohepatitis
J. Jilek Goedken Altered Cisplatin Pharmacokinetics during Nonalcoholic Steatohepatitis Contributes to Reduced Nephrotoxicity
D. Rizzolo Guo Sex Differences in Bile Acid Metabolism
M. Stofan Guo Fgf15 Overexpression and PPARa Activation as a Combination Therapy for NASH in a Mouse Model
G. Vail Roepke Organophosphate Flame Retardant Alterations to Energy Homeostasis in PPARg and Era KO Mouse Models of Diet-Induced Obesity
Molecular
Presenter Lab Presentation Title
B. Karas Cooper/Buckley Evaluation of Metastatic Pathway Inhibition by Novel Ruthenium-Based Metallodrugs Using the Zebrafish Model
N. Sparks and L. Walker Zur Nieden Tobacco-Induced Transcriptional Dysregulation Associates with Attenuation of Osteogenesis
J. Taylor J. Laskin Enzyme Kinetic Parameters for Hydrogen Peroxide Generation (Auto-Oxidation) in P450-Related Microsomal Electron Transport Chains
X. Wen Aleksunes Loss-of-Function Variant in the BCRP/ABCG2 Transporter Increases Cadmium Renal Injury In Vitro
Neurological
Presenter Lab Presentation Title
A. Eid Richardson RNA-Seq Evaluation of DDT Exposure in the Hippocampus of APOE Mice
Y. Jan J. Laskin Protection against Parathion-Induced Neurotoxicity by a Menadione/Vitamin C Combination Drug
A. Morris Hart Assessing DDT/DDE in Alzheimer’s Disease Pathways in Human Stem Cells-Derived Neurons Carrying APOE Gene Variants
C. Nadolny Richardson Regulation of Ubiquitin Specific Peptidase 2 by Farnesoid X Receptor in Glioblastoma NCI-60 Cell Lines
Pulmonary
Presenter Lab Presentation Title
Y. An J. Laskin Potential Role of Ferroptosis in Toxicity Induced by 9,10-Phenanthrenequinone in Human Lung Epithelia Calu-1 Cells
T. Banota D. Laskin The Development of Pulmonary Inflammation and Injury in a Mouse Model of Non-Alcoholic Steatohepatitis
J. Carnino Jin Effects of Ozone-Generated Microvesicles and MV-MiR-199a-3p on Inflammatory Lung Responses in Alveolar Macrophages
E. Chung Panettieri Glucocorticoids Rescue TFG-β1-Mediated β2- Adrenergic Receptor Dysfunction by Attenuating Gene Expression
C. Gardner D. Laskin Depletion of CD11b+ Alveolar Macrophages Exacerbates Lung Injury and Oxidative Stress following Ozone Inhalation
A. Gow Gow Lung Function: It’s Not Just Breathing
M. Han D. Laskin Involvement of Galectin-3 in Maintaining Barrier Integrity of Lung Vasculature
D. Laskin D. Laskin Macrophage Phenotype and Inflammation in Lung Injury and Resolution: Role of Lipid Metabolism
J. Lee D. Laskin Valproic Acid Blunts Lung Injury, Oxidative Stress, Inflammation, and Altered Pulmonary Mechanics Induced by Inhaled Ozone
C. Malcolm D. Laskin PPARγ Regulates the Inflammatory Response to Ozone-Induced Lung Injury in Mice
A. Murray D. Laskin Combination of Functional Testing with Lung Imaging to Generate Continuous Response Models
E. Parchuke Gow Effects of Chronic Pulmonary Inflammation on Ozone-Induced Alterations in the Lung Microbiome
J. Radbel D. Laskin Exacerbation of Sepsis-Induced Acute Lung Injury (ALI) by Ozone is Regulated by Macrophage Phenotypic Switching
T. Seymore D. Laskin Anti-TNFa Antibody Mitigates Sulfur Mustard-Induced Lung Injury in Rats
L.C. Smith D. Laskin Role of PPARγ in the Resolution of Ozone-Induced Lung Injury
A. Venosa Venosa Lung Epithelial Cell Susceptibility Driven by Surfactant Protein-C Mutation Enhances Ozone-Induced Toxicity
M. Wilkinson Gow OANO2 Increases the Likelihood of Survival and Resolution Signaling in Response to Bleomycin-Mediated Lung Injury
S. Xu Panettieri Free Fatty Acids Receptor 1/4 (FFAR1/4) Agonists, GW9508, and TAK875 Attenuate Agonist-Induced Shortening in Human Airway Smooth Muscle (HASM) Cells