Infertility affects over 6 million women in the child bearing age with one main cause being women with progesterone resistance have a non-receptive uterus leading to implantation failure. To understand the mechanism behind this we looked at the role of Gαq/11 signaling since it’s been shown to regulate uterine functions throughout pregnancy from the acquisition of uterine receptivity to parturition. Given the poor understanding of the role of Gαq/11 signaling during early pregnancy events generation of a mouse model of infertility, uterine specific KO of Gαq/11, was created to investigate the role of Gαq/11 signaling during the acquisition of uterine receptivity. In conclusion from our studies, we showed uterine Gαq/11 signaling regulates the progesterone dependent acquisition of uterine receptivity.