The Graduate Research Fellowship in Toxicology from Bristol-Myers Squibb Co. supports students involved in non-clinical and in vivo toxicology research. Third year Ph.D.student Gina Capece was chosen to be the 2025-2026 recipient of this competitive fellowship. Her research focuses on investigating the molecular mechanisms driving chemical- and drug-induced liver injury. The overall goal of this research is to identify the role of the enzyme peptidyl arginine deiminase-4 (PAD4) in acetaminophen (APAP)-induced acute liver injury and acute liver failure, using a mouse model of APAP overdose. APAP overdose is the leading cause of drug-induced liver injury in the United States, yet effective therapies that prevent injury progression to liver failure remain limited. The purpose of this study is to identify the cell types that express PAD4 in the APAP-injured liver and to define the contribution of PAD4 to liver repair following APAP overdose. These studies will advance our understanding of the molecular pathways driving the progression of acute liver injury to liver failure and evaluate the potential of PAD4 as a novel therapeutic target.The Fellowship will support Gina’s research costs, stipend, and allow for personalized mentoring from expert scientists at Bristol-Myers Squibb.