On December 4, 2020, Dr. Esther Haugabrooks from the Physicians Committee for Responsible Medicine gave an overview of the contemporary approaches to reduce animal usage in toxicology testing. These included in vitro, in silico and in chemico methods and the use of adverse outcome pathways. Her seminar also discussed the necessary steps for validation and implementation of these methods in toxicology risk assessment. The JGPT is grateful for her insightful and interactive seminar.