. G protein-coupled receptor signaling regulates many human airway smooth muscle (HASM) functions which are levels often associated with bronchodilator therapy for obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. The G protein signaling network modulates airway smooth muscle relaxation through the β2-adrenergic receptor (β2AR), Gs, and adenylyl cyclase axis.Our previous studies […]
