. G protein-coupled receptor signaling regulates many human airway smooth muscle (HASM) functions which are levels often associated with bronchodilator therapy for obstructive lung diseases such as asthma and chronic obstructive pulmonary disease. The G protein signaling network modulates airway smooth muscle relaxation through the β2-adrenergic receptor (β2AR), Gs, and adenylyl cyclase axis.Our previous studies […]
“My research focuses on a particular compound used in fire protection – organophosphate flame retardants (OPFR). Human exposure to OPFR has health concerns due to their endocrine disruption capacity through interactions with endogenous hormone receptors that regulate energy homeostasis. Our research has shown OPFR cause sex-dependent disruptions of energy balance in adult mice.”
In Spring 2019, scientists from Novartis conducted the “Safety Assessment of Pharmaceuticals” elective class for JGPT students and postdocs. This hands-on course provides real-world scenarios and data that are encountered in drug development. Topics covered included Safety Pharmacology, Imaging and Pathology, Carcinogenicity, Metabolites, Investigative Safety, and more. JGPT students benefit from the strong ties between […]
On Jan 10-11, 2019, the first annual Boot Camp for Risk Assessment was held in the Environmental and Occupational Health Sciences Institute at Rutgers University. Over the two days, the lecture topics included risk analysis, systematic review, data quality, weight of evidence, hazard identification, susceptible populations, exposure pathways, point-of-departure, reference values, and more. Case studies […]
I recently participated in the Genomics Workshop taught by Data Carpentry and offered through Rutgers iJOBS. Data Carpentry’s aim is to teach researchers basic concepts, skills, and tools for working with data so they can get more done in less time, and with less pain. This particular workshop taught data management and analysis techniques for […]
On Jan 18, 2019, JGPT alumni provided an overview of multiple job sectors within toxicology. Four speakers provided highlights of their former and current positions, advice for students, and answered questions from attendees. Dr. Brian Wall, Research Scientist, Colgate-Palmolive Company Dr. Allison Isola, Advanced Toxicologist, Exxonmobil Biomedical Sciences, Inc Dr. Justin Schumacher, Research Investigator […]
Three trainees from the Toxicology and Exposure Science graduate programs presented their latest research during the monthly meeting of P30 NIEHS Center for Environmental Exposures and Disease (CEED) investigators. Two Toxicology Ph.D. trainees (Ludwik Gorczyca 5th Year Student & Jeanine D’Errico 3rd Year Student) shared their latest research of placenta responses and functions. Basic, translational, […]
As part of his career development and mentorship by scientists at Bristol-Myers Squibb, Raj Shah, the 2018-9 JGPT BMS Fellow, shared his latest research findings on glutamate signaling in melanoma. This unique mentorship along with his research mentor Dr. Suzie Chen affords Raj a great opportunity for understanding the potential translation of his research findings […]
by Dahea “Diana” You This fall, I was fortunate to receive a generous funding from the Society of Toxicology Supplemental Training for Education Program (STEP) to attend a one-week comprehensive Simcyp® Workshop. This workshop was hosted by Certara and held at the Nassau Inn, Princeton NJ from October 22nd through 26th, 2018. The workshop program […]
On Nov 30, 2018, Dr. Xiaoyan Chu, Senior Principal Scientist at Merck shared her latest research findings on how endogenous biomarkers are being investigated as probes for drug-transporter interactions. Her presentation provided an overview of recently identified biomarkers for studying the inhibition of liver and kidney transporters including the current strategies, utility, limitations and future […]
