RATS Toxicity Challenge at Rutgers Day

 On Saturday April 27, 2019, the RATS embarked upon Cook Campus to welcome the NJ community to Rutgers as part of Rutgers Day. People were able to take selfies next to our famous RATS picture as well as play a game matching toxicants with target organs. Everyone learned a bit about physiology and toxicology while […]

Brushing Up on Biostatistics: Improving Toxicology Study Design and Evaluation

On May 23rd, the JGPT hosted a 3-hour bootcamp on biostatistics for current toxicology students as well as trainees and research scientists from across campus. Dr. Amy Kohtz provided case studies and a host of tools for the 25 participants to analyze their biological data. As students advance in their thesis projects and scientists prepare […]

Annual Celebration of RATS Research Accomplishments

On April 17, 2019, the Ernest Mario School of Pharmacy held its 9th annual Pharmacy Research Day. Students in the Joint Graduate Program in Toxicology presented their latest research findings ranging from oncology to liver disease to reproductive toxicology. The 2-hour dynamic event featured 114posters.  

“Rutgers Pharmaceutical Research Travel Award”

  Raj Shah, a 5th year PhD Candidate, was recently selected as a recipient of the 2018-2019 Rutgers Pharmaceutical Research Travel Award, a program that has been generously made by Dr. Paul Kurtulik, an EMSOP alumni. Raj attended the 2019 Annual Meeting of the American Association for Cancer Research (AACR) in Atlanta, Georgia. Raj’s research […]

Rutgers Scientists and Trainees Share Latest Research at SOT 2019 ToxExpo

In March 2019, the Rutgers Toxicology trainees attended the Society of Toxicology meeting in Baltimore, MD. Trainees (undergrad, grad and postdoc) presented over 35 posters and presentations throughout the week. During the meeting, Ludwik Gorczyca (Aleksunes lab) received the Sheldon Murphy Award (Mechanisms Specialty Section) and a 3rd Place Poster Award (Reproductive & Developmental Toxicology […]

2019 Society of Toxicology meeting in Baltimore, MD

 Infertility affects over 6 million women in the child bearing age with one main cause being women with progesterone resistance have a non-receptive uterus leading to implantation failure. To understand the mechanism behind this we looked at the role of Gαq/11 signaling since it’s been shown to regulate uterine functions throughout pregnancy from the acquisition of […]

2019 Society of Toxicology meeting in Baltimore, MD

  My research aims to define the effects of a small molecule, metabotropic glutamate receptor (mGluR) Group I agonist 2-chloro-5-hydroxyphenylglycine (CHPG), in a cuprizone-induced model of demyelination in mice. Demyelinating diseases such as Multiple Sclerosis can be very debilitating to patients and most of the current approved therapies treat the immunological component rather than the […]

2019 Society of Toxicology meeting in Baltimore, MD

  Syncytiotrophoblasts arise from the fusion of cytotrophoblasts, a process regulated by cyclic nucleotide signaling. Syncytiotrophoblasts express transporters, including the multidrug resistance-associated proteins (MRP) 1, 3, and 5, which regulate the intracellular concentration of cyclic nucleotides through active efflux. Understanding the interplay of cyclic nucleotides, efflux transporters, and syncytialization is important because aberrant cytotrophoblast functioning […]

2019 Society of Toxicology meeting in Baltimore, MD

My project focuses on the effects of vesicating agents, specifically nitrogen mustard (NM) on mouse skin. In these studies the epidermis is isolated and analyzed for protein changes involved in the cell cycle. A bi-phasic response was observed in proteins responsible for DNA synthesis and repair as early at 15 minutes following exposure up until 24 hours. This tells […]

2019 Society of Toxicogy meeting in Baltimore, MD

My project was a mechanistic study to determine the disposition and toxicity effects of Cadmium on wild-type and Bcrp-null mice following acute exposure. Tissues were analyzed after 24 hours post administration of 5.5 mg/kg CdCl2 to confirm what is stated in the literature. Indeed, loss of the bcrp transporter in mice led to an increase […]