Bile acids are a diverse population of amphipathic molecules synthesized through the enzymatic oxidation of cholesterol in the liver. The synthesis of bile acids has traditionally been shown to occur via two pathways. Cholesterol 7 alpha-hydroxylase (Cyp7a1) performs the initial and rate-limiting step in the classical pathway while sterol 27-hydroxylase (Cyp27a1) initiates the hydroxylation of […]
