Infertility affects over 6 million women in the child bearing age with one main cause being women with progesterone resistance have a non-receptive uterus leading to implantation failure. To understand the mechanism behind this we looked at the role of Gαq/11 signaling since it’s been shown to regulate uterine functions throughout pregnancy from the acquisition of […]
Syncytiotrophoblasts arise from the fusion of cytotrophoblasts, a process regulated by cyclic nucleotide signaling. Syncytiotrophoblasts express transporters, including the multidrug resistance-associated proteins (MRP) 1, 3, and 5, which regulate the intracellular concentration of cyclic nucleotides through active efflux. Understanding the interplay of cyclic nucleotides, efflux transporters, and syncytialization is important because aberrant cytotrophoblast functioning […]
My project is on the role of Farnesoid X Receptor (FXR) in the lung following exposure to the chemical warfare agent, nitrogen mustard. FXR is a nuclear receptor involved in lipid homeostasis and we speculate that FXR regulates differential macrophage activation by altering lung lipids
Bile acids are a diverse population of amphipathic molecules synthesized through the enzymatic oxidation of cholesterol in the liver. The synthesis of bile acids has traditionally been shown to occur via two pathways. Cholesterol 7 alpha-hydroxylase (Cyp7a1) performs the initial and rate-limiting step in the classical pathway while sterol 27-hydroxylase (Cyp27a1) initiates the hydroxylation of […]
by Dahea “Diana” You This fall, I was fortunate to receive a generous funding from the Society of Toxicology Supplemental Training for Education Program (STEP) to attend a one-week comprehensive Simcyp® Workshop. This workshop was hosted by Certara and held at the Nassau Inn, Princeton NJ from October 22nd through 26th, 2018. The workshop program […]
The MidAtlantic Society of Toxicology (MASOT) meeting was held on Oct 24, 2018 in Edison, NJ. Rutgers Ph.D. students won the top awards at the meeting. Top poster honors were awarded to Ludwik Gorczyca (1st Place), Jennifer Schaefer (2nd Place) and Kyle Saitta (3rd Place) for their outstanding research presentations.
Ludwik Gorczyca, a Ph.D. candidate in the JGPT program, has been awarded a Ruth L. Kirschstein National Research Service Award F31 grant from the NIH. This predoctoral fellowship award provides students the opportunity to obtain individualized and mentored training from leading expert faculty sponsors. Mentored training is focused on research pertaining to the missions of […]
Description: RATS Students and Postdocs received multiple honors and awards at the 2018 Society of Toxicology Meeting. Recognitions included poster competitions, travel awards, and publication honors. In addition, a number of RATS were elected to hold leadership roles as student and postdoctoral representatives for the 2018-2018 year. Congrats to all! Front row (Left to […]
The Rutgers Association of Toxicology Students (RATS) are excited to congratulate their fellow RATS, Kate Annunziato and L. Cody Smith, Ph.D. on their selection as this year’s Scala Scholars. The Scala award, honoring Dr. Robert A. Scala, is bestowed upon top predoctoral and postdoctoral candidates for their outstanding contributions to the field of […]
Dahea Diana You, PharmD and Justin Schumacher, MS, PharmD received highly competitive travel awards to attend the 38th Annual Meeting of the American College of Toxicology in Palm Springs CA. Diana also received the 2017 Best Poster Presentation Award.
